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Vipera aspis can be found in NE Spain, France, Switzerland, Germany, Italy, Slovenia. According to WHO Guidelines for the production, control and regulation of Snake Antivenom Immunoglobulins, the Vipera aspis species is of the highest medical importance in Western Europe. Buy Vipera Aspis Venom Online
The venom of Vipera aspis is used for the production of antivenom immunoglobulins aimed at these countries. The venom of Vipera aspis is also used in homeopathic remedies Vipera redi.
Vaspins A, B (PLA² inhibitors) Ammodytins I1, I2, svVEGF Toxin HF, PLA² II and III are extracted from the venom of Vipera aspis
For Research purposes: the venom of Vipera aspis is expected to contain Neurotoxins, Procoagulants and Haemorrhagins. Buy Vipera Aspis Venom Online
The variation in venom composition with geography is an essential component of intraspecific diversity in the Vipera genus, however, the sources of this variability are unknown. The diversity of snake venom is crucial for understanding venomous snake evolution as well as developing appropriate antivenoms to cure envenomations. Buy Vipera Aspis Venom Online
A geographic intraspecific variation in snake venom composition was recently reported for Vipera aspis venom in France. Since 1992, cases of human envenomation after Vipera aspis bites in southeast France involving unexpected neurological signs were regularly reported. Buy Vipera Aspis Venom Online
Because the Vaa snake genome contains genes that code for neurotoxins, we decided to look into any neurological symptoms connected with snake bites in other parts of France and neighbouring countries. Simultaneously, we used a variety of methods to characterize the venom content of snakes caught in the same places.
We conducted an epidemiological survey of snake bites in various regions of France. In parallel, we carried out the analysis of the genes and the transcripts encoding venom. We used SELDI technology to study the diversity of various venom samples. Neurological signs (mainly cranial nerve disturbances) were reported after snake bites in three regions of France: Languedoc-Roussillon, Midi-Pyrénées and Provence-Alpes-Côte Azur.
Genomes of Vipera aspis snakes from southeast France were shown to contain ammodytoxin isoforms never described in the genome of Vipera aspis from other French regions. Surprisingly, transcripts encoding venom neurotoxic were found in snakes of Massif Central region. Accordingly, SELDI analysis of venom composition confirmed the existence of a population of neurotoxic Vipera aspis snakes in the west part of the Massif Central mountains.
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Conclusions/Significance: The association of epidemiological studies to genetic, biochemical and immunochemical analyses of snake venoms allowed a good evaluation of the potential neurotoxicity of snake bites. A correlation was found between the expression of neurological symptoms in humans and the intensity of the cross-reaction of venoms with anti-ammodytoxin antibodies, which is correlated with the level of neurotoxin (vaspin and/or ammodytoxin) expression in the venom. The origin of the two recently identified neurotoxic snake populations is discussed according to venom genome and transcriptome data.
Four species of vipers of the Vipera genus live in mainland France. Two of these species have not been implicated in causing serious envenomation. Indeed the Basque viper (Vipera seoanei) and the meadow viper (Vipera ursini) are small snakes that live within a restricted area and are not medically significant. The other two French viper species, i.e., the adder (Vipera berus) and the asp viper (Vipera aspis) are larger snakes, ranging from 40 to 60 cm in length, and can cause life-threatening envenomation.
Since it is adapted to cold regions, Vipera berus can be found in Scandinavian countries beyond the Arctic polar circle. The northern half of France and the mountainous regions of central France mark the southernmost extension of the habitat of this species. Buy Vipera Aspis Venom Online
This snake is common in Sweden and England. Vipera aspis, which requires sun and warm temperatures, is found mainly in the regions south of the Loire. It can proliferate in suitable environments. Pattern markings are highly variable, even within the same population.
Our reporting of the data concerning Vipera aspis bites in Southeastern France over 13 years should provide clinicians with useful insights for the management of patients envenomed by native Vipera species, including those involving neurological toxicity. Buy Vipera Aspis Venom Online
Snake venoms are complex mixtures of biologically active proteins. They contain several enzymes and toxins that act in synergy to fulfil the two main functions of the venom are subduing and digesting prey. The diversity of snake venom within species has repeatedly been described over the last twenty years.
The variation of venom composition with geography is an important aspect of this intraspecific variability. Several species of medical importance belonging to Viperidae and Elapidae families produce different clinical symptoms across the geographical range of their distribution. The causes of this variability remain unclear. Buy Vipera Aspis Venom Online
In some cases the validity of the definition of the species is necessary and the apparent intraspecies variation is interspecies. Interspecies hybridization may be a major mechanism of diversification of the composition of snake venoms. Whatever the origin, the diversity of snake venom is important both for our understanding of venomous snake evolution and for the preparation of relevant antivenoms to treat envenomations.
Three species of venomous snakes are of medical importance in Europe: Vipera aspis, Vipera berus and Vipera ammodytes (Vam). The clinical features of Vipera aspis (Vaa) and Vipera berus berus (Vbb) envenomations are mostly local, but can be associated with systemic signs (gastrointestinal and coagulation disorders, low blood pressure) in cases of severe envenomation. Contact us for more info.
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